Invention Grant
- Patent Title: Fused aminodihydrothiazine derivatives
- Patent Title (中): 融合氨基二氢噻嗪衍生物
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Application No.: US13685109Application Date: 2012-11-26
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Publication No.: US08592408B2Publication Date: 2013-11-26
- Inventor: Adrian Hall , Christopher Neil Farthing
- Applicant: Eisai R&D Management Co., Ltd.
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: GB1101140.0 20110121
- Main IPC: C07D513/04
- IPC: C07D513/04 ; A61K31/542

Abstract:
The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine; A is CH or N; Y is methyl, ethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, difluoroethyl, methoxy, ethoxy, methoxymethyl or —C≡N; and pharmaceutically acceptable salts thereof; which compound has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.
Public/Granted literature
- US20130203740A1 FUSED AMINODIHYDROTHIAZINE DERIVATIVES Public/Granted day:2013-08-08
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