Invention Grant
US08592409B2 Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
失效
11β-羟类固醇脱氢酶的环状肼基甲酸酯和氨基脲抑制剂1
- Patent Title: Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
- Patent Title (中): 11β-羟类固醇脱氢酶的环状肼基甲酸酯和氨基脲抑制剂1
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Application No.: US12863634Application Date: 2009-01-21
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Publication No.: US08592409B2Publication Date: 2013-11-26
- Inventor: David A. Claremon , Linghang Zhuang , Yuanjie Ye , Suresh B. Singh , Colin M. Tice , Salvacion Cacatian
- Applicant: David A. Claremon , Linghang Zhuang , Yuanjie Ye , Suresh B. Singh , Colin M. Tice , Salvacion Cacatian
- Applicant Address: US PA Fort Washington
- Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee Address: US PA Fort Washington
- Agency: McCarter & English LLP
- Agent Steven G. Davis; Michael J. DeGrazia
- International Application: PCT/US2009/000421 WO 20090121
- International Announcement: WO2009/094169 WO 20090730
- Main IPC: C07D265/10
- IPC: C07D265/10 ; A61K31/417
Abstract:
This invention relates to novel compounds of the Formula (I), (Ia), (Ic), (Ie), (If), (Ig), (Ih), (Ii), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
Public/Granted literature
- US20110112082A1 CYCLIC CARBAZATE AND SEMICARBAZIDE INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 Public/Granted day:2011-05-12
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