Invention Grant
- Patent Title: Compounds and compositions as protein kinase inhibitors
- Patent Title (中): 化合物和组合物作为蛋白激酶抑制剂
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Application No.: US12936199Application Date: 2009-04-03
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Publication No.: US08592432B2Publication Date: 2013-11-26
- Inventor: Bei Chen , Tao Jiang , Thomas H. Marsilje , Pierre-Yves Michellys , Truc Ngoc Nguyen , Wei Pei , Baogen Wu , Zhaobo Gao , Yonghui Ge , Chen Huang , Yuncheng Li , Xuefeng Zhu
- Applicant: Bei Chen , Tao Jiang , Thomas H. Marsilje , Pierre-Yves Michellys , Truc Ngoc Nguyen , Wei Pei , Baogen Wu , Zhaobo Gao , Yonghui Ge , Chen Huang , Yuncheng Li , Xuefeng Zhu
- Agency: Genomics Institute of The Novartis Research Foundation
- Agent Emily Tongco Wu
- International Application: PCT/US2009/039383 WO 20090403
- International Announcement: WO2009/126515 WO 20091015
- Main IPC: A61K31/506
- IPC: A61K31/506 ; A61K31/5377 ; C07D239/42 ; C07D239/30 ; C07D295/108 ; C07D487/04 ; A61P35/00 ; A61P35/02 ; A61P35/04
Abstract:
The invention provides novel pyrimidine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, c-ros oncogene (ROS), insulin-like growth factor (IGF-1R), and/or insulin receptor (InsR) or a combination thereof.
Public/Granted literature
- US20110135668A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS Public/Granted day:2011-06-09
Information query
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