Invention Grant
- Patent Title: Compounds and compositions as protein kinase inhibitors
- Patent Title (中): 化合物和组合物作为蛋白激酶抑制剂
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Application No.: US12088649Application Date: 2006-10-20
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Publication No.: US08592433B2Publication Date: 2013-11-26
- Inventor: Advait Nagle , Nathanael S. Gray
- Applicant: Advait Nagle , Nathanael S. Gray
- Agency: Genomics Institute of The Novartis Research Foundation
- Agent Daniel E. Raymond
- International Application: PCT/US2006/041229 WO 20061020
- International Announcement: WO2007/053343 WO 20070510
- Main IPC: C07D473/30
- IPC: C07D473/30 ; C07D487/04 ; A61K31/519 ; A61K31/522 ; A61P25/28 ; A61P29/00 ; A61P35/00 ; A61P33/06 ; A61P7/02 ; A61P9/10 ; A61P17/06 ; A61P11/06
Abstract:
The invention provides a novel class of compounds having the structure of Formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Aurora-A, Axl, BMX, CHK2, c-RAF, cSRC, Fes, FGFR3, Flt3, IKKα, IR, JNK2α2, Lck, Met, MKK6, MST2, p70S6K, PDGFRα, PKA, PKD2, ROCK-II, Ros, Rsk1, SAPK2α, SAPK2β, SAPK3, SAPK4, Syk, Tie2 and TrkB kinases:
Public/Granted literature
- US20100324062A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS Public/Granted day:2010-12-23
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