Invention Grant
- Patent Title: Alpha7 nicotinic receptor selective ligands
- Patent Title (中): α7烟碱受体选择性配体
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Application No.: US13328841Application Date: 2011-12-16
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Publication No.: US08592458B2Publication Date: 2013-11-26
- Inventor: William Reade Kem , Ferenc Soti
- Applicant: William Reade Kem , Ferenc Soti
- Applicant Address: US FL Gainesville
- Assignee: University of Florida Research Foundation, Inc.
- Current Assignee: University of Florida Research Foundation, Inc.
- Current Assignee Address: US FL Gainesville
- Agency: Edwards Wildman Palmer LLP
- Agent Jeffrey D. Hsi; Peter F. Corless
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61K31/44
Abstract:
The invention relates to the design and synthesis of 3-arylidene-anabaseine compounds that exhibit enhanced selectivity toward alpha7 nicotinic receptors. The compounds are expected to be useful in treating a wide variety of conditions, including neurodegenerative conditions such as Alzheimer's Disease, neurodevelopmental diseases such as schizophrenia, and certain peripherally located inflammations mediated by macrophage infiltration.
Public/Granted literature
- US20120094943A1 ALPHA 7 NICOTINIC RECEPTOR SELECTIVE LIGANDS Public/Granted day:2012-04-19
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