Invention Grant
US08592563B2 Antibodies specific to pro-angiogenic isoforms of vascular endothelial growth factor (VEGF)
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血管内皮生长因子（VEGF）的促血管生成同种型特异性抗体
- Patent Title: Antibodies specific to pro-angiogenic isoforms of vascular endothelial growth factor (VEGF)
- Patent Title (中): 血管内皮生长因子（VEGF）的促血管生成同种型特异性抗体
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Application No.: US12739619Application Date: 2008-10-26
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Publication No.: US08592563B2Publication Date: 2013-11-26
- Inventor: David O. Bates , Steven J. Harper , Miriam Y. Mengelus , Menachem Ze'evi
- Applicant: David O. Bates , Steven J. Harper , Miriam Y. Mengelus , Menachem Ze'evi
- Applicant Address: US NJ Summit GB Bristol
- Assignee: Philogene, Inc.,University of Bristol
- Current Assignee: Philogene, Inc.,University of Bristol
- Current Assignee Address: US NJ Summit GB Bristol
- Agency: Choate, Hall & Stewart LLP
- Agent Fangli Chen; Rolando Medina
- International Application: PCT/IL2008/001410 WO 20081026
- International Announcement: WO2009/053987 WO 20090430
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K16/22
Abstract:
The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, against agonist pro-angiogenic, pro-permeability, vasodilatory isoforms of VEGF. Disclosed antibodies and antibody fragments are characterized by being capable of binding to and neutralizing pro-angiogenic forms of VEGF while not effecting isoforms of VEGF which are anti angiogenic. Methods of production and use in therapy and diagnosis, of such antibodies and antibody fragments are also provided.
Public/Granted literature
- US20100272733A1 ANTIBODIES SPECIFIC TO PRO-ANGIOGENIC ISOFORMS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) Public/Granted day:2010-10-28
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