Invention Grant
US08592643B2 Methods for introducing a human gene into a marmoset embryo for making a transgenic marmoset
有权
将人基因导入et et胚用于制备转基因m猴的方法
- Patent Title: Methods for introducing a human gene into a marmoset embryo for making a transgenic marmoset
- Patent Title (中): 将人基因导入et et胚用于制备转基因m猴的方法
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Application No.: US12865304Application Date: 2008-12-09
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Publication No.: US08592643B2Publication Date: 2013-11-26
- Inventor: Erika Sasaki , Hideyuki Okano
- Applicant: Erika Sasaki , Hideyuki Okano
- Applicant Address: JP Kawasaki-shi JP Tokyo
- Assignee: Central Institute for Experimental Animals,Keio University
- Current Assignee: Central Institute for Experimental Animals,Keio University
- Current Assignee Address: JP Kawasaki-shi JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2008-017955 20080129
- International Application: PCT/JP2008/072732 WO 20081209
- International Announcement: WO2009/096101 WO 20090806
- Main IPC: A01K67/00
- IPC: A01K67/00

Abstract:
An object of the present invention is to provide a method for introducing a gene into an embryo for production of a human disease model primate animal using a non-human primate animal such as a marmoset. The present invention relates to a method for introducing a foreign gene into an early embryo of a non-human primate animal, which comprises placing early embryos of a non-human primate in a 0.2 M to 0.3 M sucrose solution, so as to increase the volume of the perivitelline spaces, and then injecting a viral vector containing a human foreign gene operably linked to a promoter into the perivitelline spaces of the early embryos.
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