Systems and methods for analyzing dynamic occlusion during replicated excursions of virtual three-dimensional representations of a dental patient's occlusal complex are provided. The method may include scanning a patient's jaws and teeth configuration using a medical imaging system such as CBCT, laser scanners, or traditional dental impressions; creating a virtual three-dimensional representation of the patient's occlusal complex; replicating excursions of the virtual three-dimensional representation of the patient's occlusal complex based at least on virtual inter-condylar angles and distances; determining acceptable occlusal contacts and/or malocclusions within the virtual three-dimensional representation of the patient's occlusal complex based at least in part on virtual dynamic occlusion during the replicated excursions, and determining at least one virtual dental appliance and/or orthodontic repositioning of one or more teeth based at least in part on the one or more acceptable occlusal contacts and/or malocclusions within the virtual three-dimensional representation of the patient's occlusal complex.