Examples of the present invention provide a method and device for image compression coding. The method includes: obtaining a designated area selected from an image at a decoding side; determining quantization coefficients of the image to make an image compression ratio of the designated area lower than image compression ratios of areas in the image other than the designated area; and performing a compression coding on the image using the determined quantization coefficients of the image. By using the present invention, a video communication system may support a user to select an interested area in a video image, and clearly transmit the interested area selected by the user.