Techniques for mitigating interference in an asynchronous wireless network are described. A terminal may desire to communicate with a serving base station and may observe high interference from other base stations. In an aspect, some frequency resources may be reserved for sending reduce interference requests and pilots to support interference mitigation. In one design, a first station (e.g., a terminal) may send a request to reduce interference to at least one interfering station on reserved control resources. The first station may receive a pilot sent by each interfering station on reserved pilot resources. The reserved resources may be associated with data resources. The first station may estimate received signal quality of the data resources based on the pilot(s). The first station may receive data sent on the data resources by a second station (e.g., a serving base station) after the interfering station(s) have reduced interference.