A method and apparatus for self-adaptive adjustment of pilot power of Femto Cell are provided in the present disclosure, which adopt a new power control mechanism. After the pilot power of a Femto Cell is initialized, the Femto Cell determines the adjustment value of the pilot power according to the signal-to-noise ratio reported by the HUE in real time, accordingly controls the pilot power of the Femto Cell accessed by each HUE, and enables the pilot power of the current Femto Cell to just satisfy the lowest transmission signal power required by the signal of the HUE in the coverage of the Femto Cell. The present disclosure can maximally reduce the interference from the pilot power of the Femto Cell in the macro cell users and the interference between the Femto Cells, while still guarantees the lowest transmission power needed by the HUE.