Distributed computing methods and systems are disclosed, wherein intensive fatigue-risk calculations are partitioned according to available computing resources, parameters of the fatigue-risk calculation, time-sensitive user demands, and the like. Methods are disclosed wherein execution-cost functions are used to allocate accessible computing resources. Additional methods include partitioning calculation tasks by user-prioritized needs and by general mathematical features of the calculations themselves. Included herein are methods to calculate only prediction-maximum likelihoods instead of full probability distributions, to calculate prediction likelihoods using Bayesian prediction techniques (instead of full re-tabulation of all data), to collate interim results of fatigue-risk calculations where serial results can be appropriately collated (e.g., serial time-slice independence of the cumulative task involved), to use simplified (e.g., linear, first-order) approximations of richer models of fatigue prediction, to assign user-identified priorities to each computational task within a plurality of such requests, and the like.