The robust controller for nonlinear MIMO systems uses a radial basis function (RBF) neural network to generate optimal control signals abiding by constraints, if any, on the control signal or on the system output. The weights of the neural network are trained in the negative direction of the gradient of output squared error. Nonlinearities in the system, as well as variations in system parameters, are handled by the robust controller. Simulation results are included in the end to assess the performance of the proposed controller.