A bristle configuration providing enhanced cleaning of teeth. At least one elongated bristle tuft is formed to at least partially enclose an area, and a complementary-shaped tuft is provided in the at least partially enclosed area. The elongated tuft and the complementary tuft have angled profiles angled to a different degree, and preferably also in a different direction. A series of elongated tufts with angled profiles may be provided to form an overall bristle profile providing enhanced cleaning of teeth. In addition, one or more tufts may be provided along the elongated tufts to form another tuft pattern along the pattern formed by the elongated tufts. In one embodiment, the other tuft pattern presents a contoured bristle profile angled to a different degree from the profile of the elongated tufts along which the other tuft pattern is provided.