Perforating assemblies and perforating safety systems capable of being disposed in a wellbore for hydrocarbon fluid production are described. The perforating assemblies can include an isolation device that is capable of preventing a denotation train when the assemblies are in a first orientation and allowing a denotation train when the perforating assemblies are in a second orientation. The isolation device can be automatically reoriented or reconfigured upon a change in the orientation of the perforating assembly.