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US08597666B2 Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby 有权
压缩固体剂型制造工艺非常适用于由此制成的低水溶性药物和压缩固体剂型

Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby
Abstract:
A pharmaceutical formulation of compounds with low aqueous solubility and method of manufacture thereof. The formulation may include a pharmacologically active compound having low aqueous solubility and starch in the amount of greater than about 25 weight percent. A manufacturing method may include blending the active compound and starch, compressing the blend into a solid, comminuting the solid into granules, wetting the granules, drying the granules, and tabletting the dried granules to make a solid pharmaceutical formulation.
Abstract(Chinese):

低溶解度的化合物的药物制剂及其制造方法。 制剂可以包含具有低水溶性的药理活性化合物和大于约25重量％的量的淀粉。 制造方法可以包括混合活性化合物和淀粉，将共混物压制成固体，将固体粉碎成颗粒，润湿颗粒，干燥颗粒，并将干燥的颗粒压片以制成固体药物制剂。

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