Invention Grant
US08598160B2 Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
失效
环烷基内酰胺衍生物作为11-β-羟基类固醇脱氢酶1的抑制剂
- Patent Title: Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
- Patent Title (中): 环烷基内酰胺衍生物作为11-β-羟基类固醇脱氢酶1的抑制剂
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Application No.: US12867374Application Date: 2009-02-13
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Publication No.: US08598160B2Publication Date: 2013-12-03
- Inventor: David A. Claremon , Linghang Zhuang , Yuanjie Ye , Suresh B. Singh , Colin M. Tice , Robert D. Simpson
- Applicant: David A. Claremon , Linghang Zhuang , Yuanjie Ye , Suresh B. Singh , Colin M. Tice , Robert D. Simpson
- Applicant Address: US PA Fort Washington
- Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee: Vitae Pharmaceuticals, Inc.
- Current Assignee Address: US PA Fort Washington
- Agency: McCarter & English LLP
- Agent Steven G. Davis; Michael J. DeGrazia
- International Application: PCT/US2009/000908 WO 20090213
- International Announcement: WO2009/102460 WO 20090820
- Main IPC: C07D211/16
- IPC: C07D211/16 ; C07D243/04 ; C07D265/10 ; A61K31/4402 ; A61P3/04
Abstract:
This invention relates to novel compounds of the Formula (I), any of the formulas I1-I26 1a1-3-1j1-3 or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
Public/Granted literature
- US20110071139A1 Cycloalkyl Lactame Derivatives As Inhibitors Of 11-Beta-Hydroxysteroid Dehydrogenase 1 Public/Granted day:2011-03-24
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