Invention Grant
- Patent Title: Pyrazole-carboxamide derivatives as P2Y12 antagonists
- Patent Title (中): 吡唑 - 甲酰胺衍生物作为P2Y12拮抗剂
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Application No.: US12817868Application Date: 2010-06-17
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Publication No.: US08598179B2Publication Date: 2013-12-03
- Inventor: Marc Nazaré , Gernot Zech , Jochen Goerlitzer , Melitta Just , Tilo Weiss , Gerhard Hessler , Werngard Czechtizky , Sven Ruf
- Applicant: Marc Nazaré , Gernot Zech , Jochen Goerlitzer , Melitta Just , Tilo Weiss , Gerhard Hessler , Werngard Czechtizky , Sven Ruf
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: EP07291628 20071226
- Main IPC: A61K31/496
- IPC: A61K31/496 ; C07D231/22 ; C07D413/12 ; C07D417/12 ; A61K31/454 ; A61K31/506 ; C07D401/12 ; C07D401/04

Abstract:
The present invention relates to compounds of the formula I, wherein R1; R2; Z; A; B; D; Q; J; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect on platelets and thus an anti-thrombotic effect and are suitable, e.g., for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are reversible antagonists of the platelet ADP receptor P2Y12, and can in general be applied in conditions in which an undesired activation of the platelet ADP receptor P2Y12 is present or for the cure or prevention of which an inhibition of the platelet ADP receptor P2Y12 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
Public/Granted literature
- US20110039829A1 PYRAZOLE-CARBOXAMIDE DERIVATIVES AS P2Y12 ANTAGONISTS Public/Granted day:2011-02-17
Information query
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