Invention Grant
US08598316B2 Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
失效
选择性地回到恶性肿瘤前病变或恶性肿瘤的脉管系统的分子
- Patent Title: Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
- Patent Title (中): 选择性地回到恶性肿瘤前病变或恶性肿瘤的脉管系统的分子
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Application No.: US12748249Application Date: 2010-03-26
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Publication No.: US08598316B2Publication Date: 2013-12-03
- Inventor: Douglas Hanahan , Erkki Ruoslahti
- Applicant: Douglas Hanahan , Erkki Ruoslahti
- Applicant Address: US CA La Jolla US CA Oakland
- Assignee: Sanford-Burnham Medical Research Institute,The Regents of the University of California
- Current Assignee: Sanford-Burnham Medical Research Institute,The Regents of the University of California
- Current Assignee Address: US CA La Jolla US CA Oakland
- Agency: Jenkins, Wilson, Taylor & Hunt, P.A.
- Main IPC: A61K38/08
- IPC: A61K38/08 ; A61K38/00
Abstract:
The present invention provides a conjugate that contains a therapeutic moiety linked to a homing peptide or peptidomimetic which selectively homes to vasculature of pre-malignant dysplastic skin and which includes the amino acid sequence SRPRR (SEQ ID NO: 1) or a conservative variant or peptidomimetic thereof. The present invention further provides a conjugate containing a therapeutic moiety linked to a homing peptide or peptidomimetic which selectively homes to vasculature of malignant skin and which includes the amino acid sequence CGKRK (SEQ ID NO: 6) or the amino acid sequence CDTRL (SEQ ID NO: 7), or a conservative variant or peptidomimetic of one of these sequences.
Public/Granted literature
- US20110002848A1 MOLECULES THAT SELECTIVELY HOME TO VASCULATURE OF PRE-MALIGNANT DYSPLASTIC LESIONS OR MALIGNANCIES Public/Granted day:2011-01-06
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