Imaging systems may be provided with image sensors having verification circuitry. Verification circuitry may be configured to verify proper operation of the image sensor during operation. Verification circuitry may include one or more switchable voltage contacts configured to generate a voltage drop across a power supply network of a pixel array during verification operations. Verification circuitry may include a controllable voltage supply coupled to the power supply network of the pixel array. Verification image data may be generated by applying the voltage drop or by using the controllable voltage supply to supply a different supply voltage to each row of pixels prior to readout of that row. Verification image data may be read out using the same circuitry that is used to readout imaging data. Based on a comparison of the verification data with a predetermined standard, imaging systems may continue to operate normally or corrective action may be taken.