An uplink signal weighted processing method is disclosed. A first channel impulse response from a Mobile Station (MS) to a relay station, and a second channel impulse response from the relay station to a Base Station (BS) are acquired. A relay weight and a demodulation weight are determined according to the first channel impulse response and the second channel impulse response. The relay weight is sent to the relay station and the demodulation weight is sent to the BS, so as to enable the relay station to perform weighted processing on an MS uplink signal received by the relay station according to the relay weight to obtain an uplink relay weighted signal and to send the uplink relay weighted signal to the BS, and so as to enable the BS to perform demodulation weighted processing on the uplink relay weighted signal received by the BS according to the demodulation weight to obtain an uplink estimation signal corresponding to the MS uplink signal.