Certain embodiments of the present invention provide systems and methods for image layout and display on a display such as a PACS workstation display. Certain embodiments provide a method for image layout on a display. The method includes detecting an event related to movement of an image for placement on a display. The method also includes overlaying a navigation grid on at least a portion of the display. The navigation grid includes one or more sections corresponding to sections for content on the display. The method further includes indicating a section of the grid into which the image is to be positioned. In addition, the method includes updating the display to reflect the position of the image.