Systems and methods are disclosed for securing a programmable integrated circuit device against an over-voltage attack. Generally, programmable devices, such as FPGAs, contain volatile memory registers that may store sensitive information. To prevent tampering and/or reverse engineering of such a programmable device, an over-voltage detection circuit may be employed to disable the device and/or erase the sensitive information stored on the device when an over-voltage attack is suspected. In particular, once the over-voltage detection circuit detects that the voltage applied to the programmable device exceeds a trigger voltage, it may cause logic circuitry to erase the sensitive information stored on the device. Desirably, the over-voltage detection circuit includes components arranged in such a way as to render current consumption negligible when the voltage applied to the programmable device, e.g., by a battery, remains below the trigger voltage.