A package having fluid-filled chambers that form a line of contact that seals the package. The package generally defines an interior cavity accessible through an opening. Opposing portions of the opening may include at least one fluid-filled chamber to seal the package. The chamber may be held in sealing contact with an opposing structure or with each other by fastening means that hold the opposing portions together. In another embodiment, opposing chambers themselves may interlock to maintain sealed contact. The package may include an auxiliary opening so that an end user can fill the package with articles of the user's choice. The auxiliary opening can be sealed at least over a portion of its length. In another embodiment, first and second compartments are isolated by the fluid-filled chamber seal, with the seal being selectively breachable to enable transfer of product from the first to the second compartment.