Invention Grant
- Patent Title: Inhibitors of Akt activity
- Patent Title (中): Akt活性抑制剂
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Application No.: US13255785Application Date: 2010-03-10
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Publication No.: US08614221B2Publication Date: 2013-12-24
- Inventor: Weiming Fan , Thomas F. N. Haxell , Matthew G. Jenks , Nobuhiko Kawanishi , Shuliang Lee , Hao Liu , Michael J. Malaska , Joseph A. Moore, III , Yoshio Ogino , Yu Onozaki , Bharathi Pandi , Michael R. Peel , Toshihiro Sakamoto , Tony Siu
- Applicant: Weiming Fan , Thomas F. N. Haxell , Matthew G. Jenks , Nobuhiko Kawanishi , Shuliang Lee , Hao Liu , Michael J. Malaska , Joseph A. Moore, III , Yoshio Ogino , Yu Onozaki , Bharathi Pandi , Michael R. Peel , Toshihiro Sakamoto , Tony Siu
- Applicant Address: US NJ Rahway JP Chiyoda-Ku, Tokyo
- Assignee: Merck Sharp & Dohme Corp.,MSD K.K.
- Current Assignee: Merck Sharp & Dohme Corp.,MSD K.K.
- Current Assignee Address: US NJ Rahway JP Chiyoda-Ku, Tokyo
- Agent Yong Zhao; Laura M. Ginkel; Matthew A. Leff
- International Application: PCT/US2010/026796 WO 20100310
- International Announcement: WO2010/104933 WO 20100916
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D471/12
Abstract:
The instant invention provides for substituted fused naphthyridine derivatives that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
Public/Granted literature
- US20120004240A1 INHIBITORS OF AKT ACTIVITY Public/Granted day:2012-01-05
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