Invention Grant
- Patent Title: Quinone prodrug compositions and methods of use
- Patent Title (中): 喹诺酮前药组合物和使用方法
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Application No.: US11201170Application Date: 2005-08-11
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Publication No.: US08614228B2Publication Date: 2013-12-24
- Inventor: Mark A. Ashwell , Manish Tandon , Jean-Marc Lapierre , Yanbin Liu
- Applicant: Mark A. Ashwell , Manish Tandon , Jean-Marc Lapierre , Yanbin Liu
- Applicant Address: US MA Woburn
- Assignee: ArQule, Inc.
- Current Assignee: ArQule, Inc.
- Current Assignee Address: US MA Woburn
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Ivor R. Elrifi; Matthew Pavao
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A61K31/47
Abstract:
The present invention relates to quinone prodrug compositions and therapeutic methods using such prodrug compositions. Preferably, the quinone compounds of the invention are napthoquinone compounds such as β-lapachone or β-lapachone analogs. The quinone prodrug compositions of the invention exhibit improved solubility, stability, bioavailability, and pharmacokinetic properties, as well as improved plasma half-life in vivo.
Public/Granted literature
- US20060035963A1 Quinone prodrug compositions and methods of use Public/Granted day:2006-02-16
Information query
IPC分类:
