A wireless communication device includes a core logic, first and second transceiver chains, first and second antennas, and an interference processor. The core logic is coupled to both the first and second transceiver chains, which in turn are coupled to the first and second antennas, respectively. The interference processor is coupled between the first and second transceiver chains. To calibrate circuitry within the first transceiver chain using first signals generated in the first transceiver chain while the second transceiver chain is transmitting second signals via the second antenna, the interference processor connects the transmit circuit of the second transceiver chain to the receive circuitry of the first transceiver chain to form an interference feedback path that can be used to compensate for unwanted components of the second signal undesirably picked up by the first antenna.