The present invention provides methods and systems to protect an organization's secure image information from unauthorized disclosure. In one embodiment, methods and systems to generate image fingerprints are provided. The fingerprints are generated for each feature point of an image data. Because the fingerprints take into account the neighborhood features around each feature point, the image fingerprints are robust against derivative images where the original image may have been altered. Methods and systems to maintain a fingerprint database for an organization's secure image data is also provided. In one embodiment, client fingerprints are generated for image data that a user intends to transmit outside of the organization. In some embodiments, suitable security actions are initiated if any of the client fingerprints match any of the fingerprints in the fingerprint database.