An imaging reader for, and a method of, imaging targets, include a solid-state imager supported by the reader and having an array of image sensors for capturing return light from a target over a field of view, and for generating image data corresponding to the target; an application specific integrated circuit (ASIC) operatively connected to the imager via an image data bus over which the image data is transmitted from the imager to the ASIC, and via a system bus over which system data for controlling operation of the reader is transmitted, the ASIC being operative for combining the image data and the system data to form combined data; and a controller operatively connected to the ASIC, for receiving and processing the combined data from the ASIC.