A self-calibrating device for measuring intracorporeal pressure, includes: A pressure sensor having i) a test body (11) of which a segment of smaller thickness constitutes a membrane that can deform under the action of the pressure of the medium, the membrane being equipped with at least one piezoelectric transducer that can translate a mechanical stress into an electrical signal, and ii) a polarization contact, An actuator that is connected to a voltage source, having a non-deformable base, whereby at least one surface of the actuator is polarizable, the pressure sensor being placed above the actuator so that the membrane is in vertical alignment with the polarizable surface (22).