According to one embodiment, an orthopedic support for supporting a portion of a wearer's anatomy is provided. For example, the orthopedic support may be an ankle brace comprising a sheet of flexible material configured to at least partially enclose a wearer's ankle and a splint coupled to the sheet of material. The splint is configured to be positioned on a medial side of the wearer's ankle when the sheet of material is secured on the wearer's ankle and includes an undulating profile configured to conform to at least a portion of the medial side of the wearer's ankle and resist inversion of the ankle.