Invention Grant
- Patent Title: Azide modified charge sensitive channel proteins
- Patent Title (中): 叠氮改性电荷敏感通道蛋白
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Application No.: US12993130Application Date: 2009-05-26
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Publication No.: US08623325B2Publication Date: 2014-01-07
- Inventor: Marc Stefan Robillard , George Thomas Robillard , Armagan Kocer
- Applicant: Marc Stefan Robillard , George Thomas Robillard , Armagan Kocer
- Applicant Address: NL Eindhoven
- Assignee: Koninklijke Philips N.V.
- Current Assignee: Koninklijke Philips N.V.
- Current Assignee Address: NL Eindhoven
- Priority: EP08156940 20080527
- International Application: PCT/IB2009/052195 WO 20090526
- International Announcement: WO2009/144659 WO 20091203
- Main IPC: A61K49/00
- IPC: A61K49/00 ; C07K14/00 ; C07C247/04
Abstract:
The present invention describes the modification of polypeptides, more particularly channel proteins with a thiol reactive agent so as to introduce an azide group. The present invention further describes vesicles comprising channel proteins modified according to the invention, which upon reaction with a phosphine open up thereby releasing the content of the vesicles. The reagents, polypeptides and vesicles described in the present invention have in vivo and in vitro applications in both drug delivery and imaging.
Public/Granted literature
- US20110064667A1 AZIDE MODIFIED PROTEINS Public/Granted day:2011-03-17
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