Invention Grant
US08623368B2 Human recombinant monoclonal antibody that specifically binds to VCAM-1 and inhibits adhesion and transmigration between leukocytes and endothelial cells
失效
与VCAM-1特异性结合并抑制白细胞和内皮细胞之间粘附和迁移的人重组单克隆抗体
- Patent Title: Human recombinant monoclonal antibody that specifically binds to VCAM-1 and inhibits adhesion and transmigration between leukocytes and endothelial cells
- Patent Title (中): 与VCAM-1特异性结合并抑制白细胞和内皮细胞之间粘附和迁移的人重组单克隆抗体
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Application No.: US13503103Application Date: 2010-10-22
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Publication No.: US08623368B2Publication Date: 2014-01-07
- Inventor: Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Dong Eun Lee , Su Yeon Ryu , Hyun Bo Shim , Kyung Jae Kang
- Applicant: Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Dong Eun Lee , Su Yeon Ryu , Hyun Bo Shim , Kyung Jae Kang
- Applicant Address: KR
- Assignee: Hanwha Chemical Corporation
- Current Assignee: Hanwha Chemical Corporation
- Current Assignee Address: KR
- Agency: Lathrop & Gage LLP
- Agent Brian C. Trinque; Andrew T. Wilkins
- Priority: KR10-2009-0101254 20091023; KR10-2010-0103523 20101022
- International Application: PCT/KR2010/007303 WO 20101022
- International Announcement: WO2011/049412 WO 20110428
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; G01N33/53
Abstract:
The present invention relates to a human recombinant monoclonal antibody that specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, and a prophylactic and therapeutic composition for inflammatory disease or cancer comprising the same. The human recombinant monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human endothelial cell, and effectively inhibits VCAM-1-mediated adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, thereby being used for the prevention and treatment of inflammatory disease such as asthma and arthritis, transplant rejection, cardiovascular disease, and cancer.
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