Invention Grant
US08623373B2 Compositions and methods for treatment of angiogenesis in pathological lesions
有权
用于治疗病理损伤中血管生成的组合物和方法
- Patent Title: Compositions and methods for treatment of angiogenesis in pathological lesions
- Patent Title (中): 用于治疗病理损伤中血管生成的组合物和方法
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Application No.: US10204581Application Date: 2001-02-22
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Publication No.: US08623373B2Publication Date: 2014-01-07
- Inventor: Luciano Zardi , Dario Neri , Barbara Carnemolla , Fredrik Nilsson , Lorenzo Tarli , Laura Borsi , Cornelia Halin
- Applicant: Luciano Zardi , Dario Neri , Barbara Carnemolla , Fredrik Nilsson , Lorenzo Tarli , Laura Borsi , Cornelia Halin
- Applicant Address: IT Siena
- Assignee: Philogen S.p.A.
- Current Assignee: Philogen S.p.A.
- Current Assignee Address: IT Siena
- Agency: Millen, White, Zelano & Branigan, P.C.
- International Application: PCT/IB01/00382 WO 20010222
- International Announcement: WO01/62298 WO 20010830
- Main IPC: A61K39/44
- IPC: A61K39/44 ; C07K16/00
Abstract:
Treatment of lesions of pathological angiogenesis, especially tumors, rheumatoid arthritis, diabetic retinopathy, age-related muscular degeneration. and angiomas. A conjugate is used comprising a molecule that exerts a biocidal or cytotoxic effect on target cells in the lesions and an antibody directed against an extracellular matrix component which is present in such lesions. The antibody may be directed against fibronectin-2 (IL-2), doxorubicin, interleukin-12(IL-12), Interferon-γ (IFN-γ), Tumor Necrosis Factor α(TNFα) or Tissue Factor protein (which may be truncated).
Public/Granted literature
- US20040013640A1 Compositions and methods for treatment of angiogenesis in pathological lesions Public/Granted day:2004-01-22
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