Invention Grant
US08623604B2 Methods for predicting responsiveness of a cancer cell to an anti-IGFR1 antibody by analysis of mutations in PIK3CA
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通过分析PIK3CA中的突变来预测癌细胞对抗IGFR1抗体的反应性的方法
- Patent Title: Methods for predicting responsiveness of a cancer cell to an anti-IGFR1 antibody by analysis of mutations in PIK3CA
- Patent Title (中): 通过分析PIK3CA中的突变来预测癌细胞对抗IGFR1抗体的反应性的方法
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Application No.: US12878156Application Date: 2010-09-09
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Publication No.: US08623604B2Publication Date: 2014-01-07
- Inventor: Sarah Bacus
- Applicant: Sarah Bacus
- Applicant Address: US NC Durham
- Assignee: Quintiles Transnational Corp.
- Current Assignee: Quintiles Transnational Corp.
- Current Assignee Address: US NC Durham
- Agency: K&L Gates LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The present disclosure relates generally to methods and materials for determining the responsiveness of a subject with a disease or disorder to an inhibitor of a receptor tyrosine kinase including, for example, IGF1R. Such methods may comprise obtaining a biological sample from the subject, assaying the biological sample for one or more PIK3CA mutations, determining if one or more PIK3CA mutations are present in the biological sample, and employing the determination of one or more PIK3CA mutations in the biological sample to predict responsiveness of the subject to the receptor tyrosine kinase inhibitor.
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