Invention Grant
- Patent Title: Method for measuring glycoprotein, method for examining liver disease, reagent for quantitative determination of glycoprotein, and glycan-marker glycoprotein as an index for clinical conditions of liver disease
- Patent Title (中): 糖蛋白测定方法，肝脏疾病检测方法，糖蛋白定量检测试剂，聚糖标记糖蛋白作为肝病临床病情指标
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Application No.: US13374807Application Date: 2012-01-13
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Publication No.: US08623608B2Publication Date: 2014-01-07
- Inventor: Hisashi Narimatsu , Yuzuru Ikehara , Atsushi Kuno , Maki Sogabe , Yasuhito Tanaka , Masashi Mizokami , Kiyoaki Ito , Shunsuke Matsubara , Chikayuki Tsuruno , Youichi Takahama , Takashi Kagawa , Shinya Nagai
- Applicant: Hisashi Narimatsu , Yuzuru Ikehara , Atsushi Kuno , Maki Sogabe , Yasuhito Tanaka , Masashi Mizokami , Kiyoaki Ito , Shunsuke Matsubara , Chikayuki Tsuruno , Youichi Takahama , Takashi Kagawa , Shinya Nagai
- Applicant Address: JP Hyogo JP Tokyo JP Aichi JP Tokyo
- Assignee: Sysmex Corporation,National Institute of Advanced Industrial Science and Technology,Nagoya University,National Center for Global Health and Medicine
- Current Assignee: Sysmex Corporation,National Institute of Advanced Industrial Science and Technology,Nagoya University,National Center for Global Health and Medicine
- Current Assignee Address: JP Hyogo JP Tokyo JP Aichi JP Tokyo
- Agency: Brinks Gilson & Lione
- Priority: JP2009-165795 20090714; JP2009-287243 20091218
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/543
Abstract:
An object of the present invention is to provide a method for measuring a glycan-marker glycoprotein, by which liver disease can be detected with higher accuracy than is possible with conventional methods. Also, an object of the present invention is to provide a method for examining liver disease, by which liver disease can be detected with higher accuracy than is possible with conventional methods. Disclosed is a method for measuring at least one glycoprotein selected from alpha-1-acid glycoprotein (AGP) and Mac-2-binding protein (M2BP) contained in a sample collected from a subject, comprising: measuring AGP binding to a first lectin selected from AOL and MAL, when the glycoprotein is AGP; and measuring M2BP binding to a second lectin selected from WFA, BPL, AAL, RCA120, and TJAII, when the glycoprotein is M2BP.
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