Invention Grant
- Patent Title: Antisense oligonucleotide modulation of STAT3 expression
- Patent Title (中): STAT3表达的反义寡核苷酸调节
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Application No.: US13451438Application Date: 2012-04-19
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Publication No.: US08623643B2Publication Date: 2014-01-07
- Inventor: James G. Karras
- Applicant: James G. Karras
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Knobbe Martens
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C07H21/04 ; C07H21/02
Abstract:
Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression and for promotion of apoptosis are provided. Methods for treatment of diseases, particularly inflammatory diseases and cancers, associated with overexpression or constitutive activation of STAT3 or insufficient apoptosis are also provided.
Public/Granted literature
- US20120202874A1 ANTISENSE OLIGONUCLEOTIDE MODULATION OF STAT3 EXPRESSION Public/Granted day:2012-08-09
Information query
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