Invention Grant
- Patent Title: Nuclear factor κB inducing factor
- Patent Title (中): 核因子κB诱导因子
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Application No.: US13157798Application Date: 2011-06-10
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Publication No.: US08623831B2Publication Date: 2014-01-07
- Inventor: Patrice Denefle , Thomas F. Haws , June M. Kaplow , Marie Rosier
- Applicant: Patrice Denefle , Thomas F. Haws , June M. Kaplow , Marie Rosier
- Applicant Address: US NJ Bridgewater
- Assignee: Aventis Pharmaceuticals Inc.
- Current Assignee: Aventis Pharmaceuticals Inc.
- Current Assignee Address: US NJ Bridgewater
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Priority: GB0018307 20000726
- Main IPC: A61K38/17
- IPC: A61K38/17 ; C07K14/47
Abstract:
The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.
Public/Granted literature
- US20110245471A1 NUCLEAR FACTOR kappaB INDUCING FACTOR Public/Granted day:2011-10-06
Information query
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