Invention Grant
- Patent Title: Modulation of growth hormone receptor expression and insulin-like growth factor expression
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Application No.: US12953105Application Date: 2010-11-23
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Publication No.: US08623836B2Publication Date: 2014-01-07
- Inventor: George Tachas , Kenneth Dobie , Ravi Jain , Christopher Belyea , Mark Heffernan
- Applicant: George Tachas , Kenneth Dobie , Ravi Jain , Christopher Belyea , Mark Heffernan
- Applicant Address: US CA Carlsbad AU Toorak, Victoria
- Assignee: Isis Pharmaceuticals, Inc.,Antisense Therapeutics Ltd.
- Current Assignee: Isis Pharmaceuticals, Inc.,Antisense Therapeutics Ltd.
- Current Assignee Address: US CA Carlsbad AU Toorak, Victoria
- Agency: Knobbe Martens Olson & Bear LLP
- Main IPC: C12N15/11
- IPC: C12N15/11 ; A61K48/00 ; C07H21/02 ; C07H21/04
Abstract:
Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The compositions comprise oligonucleotides, targeted to nucleic acid encoding growth hormone receptor. Methods of using these compounds for modulation of growth hormone receptor expression and for diagnosis and treatment of disease associated with expression of growth hormone receptor and/or insulin-like growth factor-I are provided. Diagnostic methods and kits are also provided.
Public/Granted literature
- US20110092572A1 MODULATION OF GROWTH HORMONE RECEPTOR EXPRESSION AND INSULIN-LIKE GROWTH FACTOR EXPRESSION Public/Granted day:2011-04-21
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