Invention Grant
US08623844B2 Fosaprepitant dimeglumine intermediate, neutral fosaprepitant, and amorphous fosaprepitant dimeglumine and processes for their preparations
有权
无限制性二甲氰菊酯中间体，中性fosaprepitant和无定形fosaprepitant二甲氰菊酯及其制备方法
- Patent Title: Fosaprepitant dimeglumine intermediate, neutral fosaprepitant, and amorphous fosaprepitant dimeglumine and processes for their preparations
- Patent Title (中): 无限制性二甲氰菊酯中间体，中性fosaprepitant和无定形fosaprepitant二甲氰菊酯及其制备方法
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Application No.: US13003885Application Date: 2009-07-17
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Publication No.: US08623844B2Publication Date: 2014-01-07
- Inventor: Navin Ganesh Bhatt , Nikhil Rasiklal Trivedi , Mahesh Khedekar , Sukumar Sinha , Mubeen Ahmed Khan , Ramjilal Yadav
- Applicant: Navin Ganesh Bhatt , Nikhil Rasiklal Trivedi , Mahesh Khedekar , Sukumar Sinha , Mubeen Ahmed Khan , Ramjilal Yadav
- Agency: M. Carmen & Associates, PLLC
- Priority: IN1510/MUM/2008 20080717; IN2154/MUM/2008 20081008; IN690/MUM/2009 20090324
- International Application: PCT/IN2009/000408 WO 20090717
- International Announcement: WO2010/018595 WO 20100218
- Main IPC: A61K31/675
- IPC: A61K31/675 ; C07D413/02
Abstract:
The present invention generally relates to a process for the preparation of fosaprepitant dimeglumine intermediate and its use in the preparation of fosaprepitant dimeglumine; to a neutral form of fosaprepitant in a solid state and processes for the preparation thereof; and to a stable amorphous fosaprepitant dimeglumine, having a stability at temperatures of about 2° C. to about 8° C. and at a relative humidity below at least 60%; and a process for the preparation thereof.
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