Invention Grant
- Patent Title: Diazeniumdiolate cyclohexyl derivatives
- Patent Title (中): 二氮烯二硫代环己基衍生物
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Application No.: US13698444Application Date: 2011-05-16
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Publication No.: US08623846B2Publication Date: 2014-01-07
- Inventor: Amjad Ali , Lin Yan , Pei Huo , Ravi Nargund
- Applicant: Amjad Ali , Lin Yan , Pei Huo , Ravi Nargund
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Richard S. Parr; Catherine D. Fitch
- International Application: PCT/US2011/036607 WO 20110516
- International Announcement: WO2011/146371 WO 20111124
- Main IPC: A61K31/655
- IPC: A61K31/655 ; C07C245/02 ; C09B44/02

Abstract:
A compound having the structure (I) or a pharmaceutically acceptable salt thereof, wherein R3 is hydrogen, deuterium, —OH, —OC1-6alkyl, or halogen; R8 is hydrogen, deuterium, or C1-6alkyl; R11 and R12 are independently hydrogen, —C1-6alkyl, —OH, —OC1-6alkyl, or halogen; R13 and R14 are independently —C1-6alkyl, —(CH2)1-2OH, or —OC1-6alkyl, or, together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclic ring containing one nitrogen atom and 0 or 1 oxygen atoms, wherein said ring is unsubstituted or mono-, di- or tri-substituted with halogen or —C1-6alkyl; R15 is —C(O)OH, —C(O)OCH2CH2N+CH3)3 wherein n is 0, 1 or 2, —C(O)NHCH(R17)OR16, or —C(O)NHCH(R17)C(O)NHCH(R18)C(O)OR16; R16 is hydrogen, C1-6alkyl, or (CH2)1-2N+R19R20R21; R1, R2, R4, R5, R6, R7, R9, R10, R17, R18, R19, R20, and R21 are independently hydrogen or —C1-6alkyl; and stereoisomers thereof, and pharmaceutically acceptable salts thereof, and pharmaceutically acceptable salts of stereoisomers thereof.
Public/Granted literature
- US20130059823A1 Diazeniumdiolate Cyclohexyl Derivatives Public/Granted day:2013-03-07
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