Invention Grant
US08623850B2 15, 16-methylene-17-(1′-propenyl)-17,3′-oxidoestra-4-en-3-one derivative, use thereof, and medicament containing said derivative
失效
15，16-亚甲基-17-（1'-丙烯基）-17,3'-氧代雌-4-烯-3-酮衍生物及其用途，以及含有所述衍生物
- Patent Title: 15, 16-methylene-17-(1′-propenyl)-17,3′-oxidoestra-4-en-3-one derivative, use thereof, and medicament containing said derivative
- Patent Title (中): 15，16-亚甲基-17-（1'-丙烯基）-17,3'-氧代雌-4-烯-3-酮衍生物及其用途，以及含有所述衍生物
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Application No.: US12810857Application Date: 2008-12-23
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Publication No.: US08623850B2Publication Date: 2014-01-07
- Inventor: Ulrich Klar , Joachim Kuhnke , Rolf Bohlmann , Jan Hübner , Sven Ring , Thomas Frenzel , Frederik Menges , Steffen Borden , Hans-Peter Muhn , Katja Prelle
- Applicant: Ulrich Klar , Joachim Kuhnke , Rolf Bohlmann , Jan Hübner , Sven Ring , Thomas Frenzel , Frederik Menges , Steffen Borden , Hans-Peter Muhn , Katja Prelle
- Applicant Address: DE Monheim
- Assignee: Bayer Intellectual Property GmbH
- Current Assignee: Bayer Intellectual Property GmbH
- Current Assignee Address: DE Monheim
- Agent Thomas C. Blankinship
- Priority: DE102007063496 20071229
- International Application: PCT/EP2008/011164 WO 20081223
- International Announcement: WO2009/083271 WO 20090709
- Main IPC: A61K31/56
- IPC: A61K31/56 ; A61K31/58
Abstract:
The invention relates to 15,16-methylene-17-(1′-propenyl)-17-3′-oxidoestra-4-en-3-one derivatives with the general chemical formula I, where the Z, R4, R6a, R6b, R7 and R18 have the meanings stated in claim 1, and solvates, hydrates and salts thereof, including all crystal modifications and all stereoisomers of these compounds. The invention also relates to the use of these derivatives for the production of a drug for oral contraception and for the treatment of pre-, peri- and postmenopausal problems and drugs which contain such derivatives, in particular use in the aforesaid indications. The derivatives according to the invention have a progestational and in preferable cases also an antimineralcorticoid and neutral to slight androgenic activity.
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