Invention Grant
US08623853B2 Treatment of cancers characterized by chromosomal rearrangement of the NUT gene
有权
以NUT基因染色体重排为特征的癌症的治疗
- Patent Title: Treatment of cancers characterized by chromosomal rearrangement of the NUT gene
- Patent Title (中): 以NUT基因染色体重排为特征的癌症的治疗
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Application No.: US13055381Application Date: 2009-07-21
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Publication No.: US08623853B2Publication Date: 2014-01-07
- Inventor: Christopher French , Jon Aster , Matthias Hofer , James Bradner
- Applicant: Christopher French , Jon Aster , Matthias Hofer , James Bradner
- Applicant Address: US MA Boston US MA Boston
- Assignee: The Brigham and Women's Hospital, Inc.,Dana-Farber Cancer Institute, Inc.
- Current Assignee: The Brigham and Women's Hospital, Inc.,Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston US MA Boston
- Agency: Law Office of: Michael A. Sanzo, LLC
- International Application: PCT/US2009/051328 WO 20090721
- International Announcement: WO2010/011700 WO 20100128
- Main IPC: A01N43/00
- IPC: A01N43/00 ; A01N43/40 ; A01N43/38 ; A01N43/08 ; A01N37/28 ; A61K31/33 ; A61K38/00 ; A61K38/12 ; A61K31/44 ; A61K31/405 ; A61K31/34 ; A61K31/205
Abstract:
The present invention is directed, inter alia, to methods of treating NUT midline carcinoma (NMC) by administering compounds that promote increased histone acetylation. The invention also includes assay methods for determining the responsiveness of NMC to specific histone deacetylases and other compounds.
Public/Granted literature
- US20110213012A1 Treatment of Cancers Characterized by Chromosomal Rearrangement of the NUT Gene Public/Granted day:2011-09-01
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