Invention Grant
US08623857B2 N-phenyl imidazole carboxamide inhibitors of 3-phosphoinositide-dependent protein kinase-1
失效
3-磷酸肌醇依赖性蛋白激酶-1的N-苯基咪唑甲酰胺抑制剂
- Patent Title: N-phenyl imidazole carboxamide inhibitors of 3-phosphoinositide-dependent protein kinase-1
- Patent Title (中): 3-磷酸肌醇依赖性蛋白激酶-1的N-苯基咪唑甲酰胺抑制剂
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Application No.: US13699547Application Date: 2011-05-24
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Publication No.: US08623857B2Publication Date: 2014-01-07
- Inventor: Hon-Chung Tsui , Sunil Paliwal , Hyunjin M. Kim , Angela D. Kerekes , Mary Ann Caplen , Sara J. Esposite , Brian A. McKittrick , Thierry Olivier Fischmann , Ronald J. Doll , Matthew Paul Rainka , Ang Li
- Applicant: Hon-Chung Tsui , Sunil Paliwal , Hyunjin M. Kim , Angela D. Kerekes , Mary Ann Caplen , Sara J. Esposite , Brian A. McKittrick , Thierry Olivier Fischmann , Ronald J. Doll , Matthew Paul Rainka , Ang Li
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Yong Zhao; Laura M. Ginkel
- International Application: PCT/US2011/037651 WO 20110524
- International Announcement: WO2011/149874 WO 20111201
- Main IPC: C07D498/08
- IPC: C07D498/08 ; C07D243/00 ; C07D401/14 ; C07D409/14 ; C07D405/14 ; C07D413/14 ; C07D403/04 ; A61K31/5386 ; A61K31/5377 ; A61K31/506 ; A61K31/551 ; A61K31/454 ; A61K31/4545 ; A61K31/4178 ; A61K31/437 ; A61K31/4995 ; A61K45/06
Abstract:
The present invention provide Imidazole Carboxamide Compounds of Formula (I): wherein D, T, R1, R2, R3, and R6 are as defined herein, and pharmaceutically acceptable salts of such Imidazole Carboxamide Compounds. The Imidazole Carboxamide Compounds are useful in the treatment of cancer and other aberrant conditions that result from overstimulation of the PDK-1 signaling pathway.
Public/Granted literature
- US20130079326A1 N-PHENYL IMIDAZOLE CARBOXAMIDE INHIBITORS OF 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 Public/Granted day:2013-03-28
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