Invention Grant
- Patent Title: 4-phenylamino-quinazolin-6-yl-amides
- Patent Title (中): 4-苯基氨基 - 喹唑啉-6-基 - 酰胺
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Application No.: US13914410Application Date: 2013-06-10
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Publication No.: US08623883B2Publication Date: 2014-01-07
- Inventor: Stephen Alan Fakhoury , Helen Tsenwhei Lee , Jessica Elizabeth Reed , Kevin Matthew Schlosser , Karen Elaine Sexton , Haile Tecle , Roy Thomas Winters
- Applicant: Warner-Lambert Company LLC
- Applicant Address: US NJ Morris Plains
- Assignee: Warner-Lambert Company LLC
- Current Assignee: Warner-Lambert Company LLC
- Current Assignee Address: US NJ Morris Plains
- Agent Stephen D. Prodnuk; Suzanne M. Bates
- Main IPC: A01N43/54
- IPC: A01N43/54 ; A61K31/519 ; C07D239/72 ; C07D401/00

Abstract:
This invention provides quinazoline compounds of the formula: wherein: R1 is halo; R2 is H or halo; R3 is a) C1-C3 alkyl, optionally substituted by halo; or b) —(CH2)n-morpholino, —(CH2)n-piperidine, —(CH2)n-piperazine, —(CH2)n-piperazine-N(C1-C3 alkyl), —(CH2)n-pyrrolidine, or —(CH2)n-imidazole; n is 1 to 4; R4 is —(CH2)m-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C1-C3 alkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH2, NH(C1-C3 alkyl) or N(C1-C3 alkyl)2; m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.
Public/Granted literature
- US20130274275A1 4-PHENYLAMINO-QUINAZOLIN-6-YL-AMIDES Public/Granted day:2013-10-17
Information query
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