Invention Grant
US08623903B2 Indolecarboxylic acid derivative having PGD2 receptor antagonistic activity
失效
具有PGD2受体拮抗活性的吲哚羧酸衍生物
- Patent Title: Indolecarboxylic acid derivative having PGD2 receptor antagonistic activity
- Patent Title (中): 具有PGD2受体拮抗活性的吲哚羧酸衍生物
-
Application No.: US13368687Application Date: 2012-02-08
-
Publication No.: US08623903B2Publication Date: 2014-01-07
- Inventor: Akira Kugimiya , Yuki Tachibana
- Applicant: Akira Kugimiya , Yuki Tachibana
- Applicant Address: JP Osaka
- Assignee: Shionogi & Co., Ltd.
- Current Assignee: Shionogi & Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2005-257358 20050906
- Main IPC: A61K31/416
- IPC: A61K31/416 ; C07D231/56

Abstract:
The present invention provides an indolecarboxylic acid derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases.A compound of the general formula (I): wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the formula of —X1═X2—X3═X4— is a formula of —C(R1)═C(R2)—C(R3)═C(R4)— etc.; X5 is C(R5) or N; R1, R2, R3, R4 and R5 is independently a hydrogen atom, a halogen atom etc; R6 is a formula of —Z—R10 etc. wherein Z is alkylene etc., and R10 is carboxy etc.; R7 is optionally substituted alkyloxy etc.; R8 is independently a halogen atom etc.; R9 is independently optionally substituted alkyl etc.; Y is a single bond etc.; n is 0 etc.; q is 0 etc.; a pharmaceutically acceptable salt or a solvate thereof.
Public/Granted literature
- US20120142687A1 INDOLECARBOXYLIC ACID DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY Public/Granted day:2012-06-07
Information query
IPC分类: