Invention Grant
- Patent Title: Lipidated imidazoquinoline derivatives
- Patent Title (中): 脂质咪唑并喹啉衍生物
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Application No.: US13125342Application Date: 2009-10-23
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Publication No.: US08624029B2Publication Date: 2014-01-07
- Inventor: David A. Johnson
- Applicant: David A. Johnson
- Applicant Address: BE Rixensart
- Assignee: GlaxoSmithKline Biologicals S.A.
- Current Assignee: GlaxoSmithKline Biologicals S.A.
- Current Assignee Address: BE Rixensart
- Agent Michael M. Conger
- International Application: PCT/US2009/061867 WO 20091023
- International Announcement: WO2010/048520 WO 20100429
- Main IPC: C07F9/06
- IPC: C07F9/06
Abstract:
The compounds of the subject invention are adjuvant molecules that comprise a imidazoquinoline molecule covalently linked to a phospho- or phosphonolipid group. The compounds of the invention have been shown to be inducers of interferon-a, IL-12 and other immunostimulatory cytokines and possess an improved activity profile in comparison to known cytokine inducers when used as adjuvants for vaccine antigens.
Public/Granted literature
- US20110282061A1 Lipidated Imidazoquinoline Derivatives Public/Granted day:2011-11-17
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