Invention Grant
- Patent Title: N-demethylation of 6-keto morphinans
- Patent Title (中): 6-酮吗啡的N-去甲基化
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Application No.: US13196929Application Date: 2011-08-03
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Publication No.: US08624030B2Publication Date: 2014-01-07
- Inventor: Peter X. Wang , Tao Jiang , David W. Berberich , Subo Liao
- Applicant: Peter X. Wang , Tao Jiang , David W. Berberich , Subo Liao
- Applicant Address: US MO Hazelwood
- Assignee: Mallinckrodt LLC
- Current Assignee: Mallinckrodt LLC
- Current Assignee Address: US MO Hazelwood
- Main IPC: C07D489/02
- IPC: C07D489/02 ; C07D489/08
Abstract:
The present invention provides processes for the demethylation of an N-methyl morphinan comprising a ketone functional group. In particular, the invention provides methods for the protection of the ketone functional group such that impurities are not generated during the demethylation of the N-methyl morphinan.
Public/Granted literature
- US20120035366A1 N-Demethylation of 6-Keto Morphinans Public/Granted day:2012-02-09
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