Circuits and methods to achieve a most efficient driver for white LEDs are disclosed. Switching Losses associated with the switching activity of a boost converter and mainly depending on clock frequency and total capacitance at the switching nodes and conduction losses associated with the current flowing in the boost converter and mainly depending on the series resistance of the elements in the regulation loop are minimized by using a size programmable NFET power switch with constant current limit, a very low voltage and accurate programmable current source, a programmable reference voltage for the error amplifier, and a PWM generator with programmable clock frequency. A limited number of configuration windows corresponding to a set of programmable values (OTP registers) for specific ranges of the current fed to the WLEDs.