A signal interference handling method adapted to a cellular system, and a system and an apparatuses using the same are provided, where the cellar system includes a macro/micro cell base station (MBS), a home base station (HBS), and a MBS-served mobile station (m-MS), and the signal interference handling method includes steps. The m-MS detects whether there is mutual interference. The m-MS sends an interference mitigation (IM) request to the HBS if there is mutual interference. The HBS enters a low duty mode (LDM) after the HBS receives the IM request.